MOTS-c (human)

Description

MOTS-c human is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the AMPK/PGC-1? pathway to enhance insulin sensitivity. MOTS-c human inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-?B inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c human has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders.