mPGES1-IN-7

Description

mPGES-1-IN-2 compound III is a benzimidazole-based mPGES-1 inhibitor that also inhibits adipophysin PGD synthase I-PGDS 5 ?M, IR=60 % . mPGES-1-IN-2 reduces PGE2 production and tends to reduce levels of other prostaglandins. mPGES-1-IN-2 effectively inhibits acute inflammation in an air sac model stimulated by Carrageenan HY-125474 in mice.