MRCKG Rabbit Polyclonal Antibody

Description

EnkiLife offers the MRCKG Rabbit Polyclonal Antibody. This antibody reacts with Human,Rat,Mouse species and is suitable for WB,ELISA application. Alternative Names of Immunogen: CDC42BPG DMPK2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,ELISA 1:5000-1:20000 Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. function:May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation. similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. similarity:Contains 1 AGC-kinase C-terminal domain. similarity:Contains 1 CNH domain. similarity:Contains 1 CRIB domain. similarity:Contains 1 PH domain. similarity:Contains 1 phorbol-ester/DAG-type zinc finger. similarity:Contains 1 protein kinase domain. subcellular location:Concentrates at the leading edge of cells. subunit:Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42. tissue specificity:Expressed in heart and skeletal muscle.