MRT-2359

Description

MRT-2359 is a potent, orally active and selective GSPT1 depressant IC50: 30 nM and 300 nM that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer NSCLC and small cell lung cancer SCLC with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research.