GENERAL CATALOGUE
MRTX-EX185 formic
HY-145962A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-145962A
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Catalog No: HY-145962A
CAS No: 2988148-70-3
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
MRTX-EX185 formic is a potent KRAS G12D inhibitor with an IC50 of 90 nM. MRTX-EX185 formic can binds both GDP-loaded and active GNP states of KRAS and KRAS G12D . MRTX-EX185 formic exhibits broad-spectrum binding properties with IC50s of 110, 290, 130 and 240 nM for KRAS WT, KRAS G12C , KRAS Q61H , KRAS G13D . MRTX-EX185 formic also binds GDP-loaded HRAS. MRTX-EX185 formic can be used to study various RAS-driven tumors such as pancreatic cancer .
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