GENERAL CATALOGUE
MS154
HY-141640 · 1 mg
MedChemExpress · Cat: HY-141640
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Catalog No: HY-141640
CAS No: 2550393-21-8
Category: JAK STAT Signaling
Pack Size: 1 mg
Brand: MedChemExpress
Description
MS154 is a first-in-class E3 ligase cereblon-recruited EGFR degrader with Kd values of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutant, respectively. MS154 potently induces degradation of mutant, but not wild-type, EGFR in cancer cell lines in an E3 ligase-dependent manner. MS154 exhibits anticancer effects against lung cancer blue: E3 ligase ligand HY-103596 ; black: linker HY-W096167 ; pink: EGFR ligand HY-168305 .
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