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MS177
GENERAL CATALOGUE

MS177

HY-148333 · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-148333

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medchemexpress.com/ms177.html
Catalog No: HY-148333
CAS No: 2225938-86-1
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 C24 IC50 : 12 nM. MS177 effectively depletes both canonical EZH2-PRC2 and noncanonical EZH2-cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest.

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