GENERAL CATALOGUE
MS1943
HY-133129 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-133129
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Catalog No: HY-133129
CAS No: 2225938-17-8
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
MS1943 is an orally active, PROTAC-based, selective degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency IC50=120 nM in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2. Structure Note: RED, EZH2 ligand HY-148458 ; Blue, Hyt HY-W001578 .
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