GENERAL CATALOGUE
MS2133
HY-173422 · 50 mg
MedChemExpress · Cat: HY-173422
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medchemexpress.com/ms2133.html
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Catalog No: HY-173422
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
MS2133 is a DOT1L PROTAC degrader. MS2133 promotes ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells DC50: 56 nM and 25 nM, respectively , and reduces H3K79 methylation. MS2133 inhibits the growth of MLL-r leukemia cells and has anticancer activity. Pink: DOT1L ligand HY-173423 ; Blue: E3 ligase VHL ligand HY-47070 ; Black: Linker HY-79577 ; E3 ligase VHL ligand-linker conjugate HY-173424 .
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