GENERAL CATALOGUE
MS39
HY-157581 · 1 mg
MedChemExpress · Cat: HY-157581
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Catalog No: HY-157581
CAS No: 2675490-92-1
Category: JAK STAT Signaling
Pack Size: 1 mg
Brand: MedChemExpress
Description
MS39 compound 6 is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N- 3-Chloro-4-fluorophenyl -7-methoxy-6- 3- piperazin-1-yl propoxy quinazolin-4-amine HY-W109039 red part , E3 ligase ligand S,R,S -AHPC HY-125845 blue part and PROTAC Linker Undecanedioic acid HY-W014125 black part , among which the conjugate of E3 ubiquitin ligase ligand + Linker is S,R,S -AHPC-CO-C9-acid HY-139345 . MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells.
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