GENERAL CATALOGUE
MS41
HY-169093 · 5 mg
MedChemExpress · Cat: HY-169093
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Catalog No: HY-169093
CAS No: 2768610-97-3
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
MS41 is a selective eleven-nineteen leukemia ENL PROTAC degrader, with DC50s of 3.50 nM MV4;11 , 2.84 nM SEMK2 , 3.03 nM Jurkat , and 26.58 nM KASUMI1 , respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand HY-169094 . Black: linker HY-W105744 . Blue: VHL ligand HY-112078 .
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