GENERAL CATALOGUE
MS4322
HY-141877 · 1 mg
MedChemExpress · Cat: HY-141877
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Catalog No: HY-141877
CAS No: 2375432-47-4
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
MS4322 YS43-22 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 ?M in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. Pink: PRMT5 ligand HY-173092 ; Blue: E3 ligase ligand HY-112078 ; Black: linker HY-124780 ; E3+linker HY-173093 .
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