GENERAL CATALOGUE
MS479
HY-176035 · 50 mg
MedChemExpress · Cat: HY-176035
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Catalog No: HY-176035
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
MS479 is a BRD4 PROTAC degrader. MS479 binds BRD4-BD2 and GLP with high affinities BRD4-BD2: Kd = 200 nM; GLP: Kd = 306 nM . MS479 can reduce the protein level of BRD4 short isoform. MS479 recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein. MS479 can be used to inhibit the proliferation of colorectal cancer cells. Pink: BRD4 ligand HY-78695 ; Blue: GLP ligand HY-176036 ; Black: linker HY-176037 ; GLP ligand+linker: HY-176038 .