MS8511

Description

MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC50 values of 100 nM G9a and 140 nM GLP , and Kd values of 44 nM G9a and 46 nM GLP . MS8511 reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer, and other disease such as AlzheimerAAasAasAas disease AD , sickle cell disease, Prader?Willi syndrome PWS .