GENERAL CATALOGUE
MS9449
HY-147942 · 5 mg
MedChemExpress · Cat: HY-147942
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Catalog No: HY-147942
CAS No: 2772612-96-9
Category: JAK STAT Signaling
Pack Size: 5 mg
Brand: MedChemExpress
Description
MS9449 is a potent PROTAC EGFR degrader with Kds of 17 nM and 10 nM for EGFR WT and EGFR L858R, respectively. MS9449 effectively induces degradation of mutant EGFRs through both the ubiquitin/proteasome system UPS and autophagy/lysosome pathways. MS9449 potently inhibits the proliferation of NSCLC cells. MS9449 can be used for researching anticancer.
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