GENERAL CATALOGUE
MSA-2
HY-136927 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-136927
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medchemexpress.com/msa-2.html
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Catalog No: HY-136927
CAS No: 129425-81-6
Category: Immunology Inflammation
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 ?M for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-? secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models.
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