MSRV-IN-1

Description

MSRV-IN-1 Compound M3 is an inhibitor targeting aquatic rhabdoviruses such as MSRV, SVCV and IHNV . Its IC50 values for inhibiting MSRV, SVCV and IHNV are 0.92 ?M, 2.92 ?M and 2.78 ?M respectively. MSRV-IN-1 does not act directly on the virions but rather inhibits viral replication by altering the cell cycle arrest state in the S phase induced by the virus and disrupting the viral replication environment. When administered intraperitoneally at a dose of 20 mg/kg, MSRV-IN-1 can significantly increase the survival rate of largemouth bass infected with MSRV by 35.98 % and reduce the viral loads in the liver, spleen and kidney. MSRV-IN-1 can be used in the research of diseases related to rhabdoviruses in aquaculture.