Mtb-IN-10

Description

Mtb-IN-10 Compound P15 is a Rv1625c/Cya activator that regulates cAMP metabolism to influence the growth of Mycobacterium tuberculosis Mtb . Mtb-IN-10 exhibits an EC50 of 1.96 AAasAasAAmuM in an Mtb-infected macrophage model and demonstrates 58.0 % oral bioavailability in mice at a 20 mg/kg dose. It may regulate intracellular signaling and disrupt cholesterol metabolism in Mtb, thereby inhibiting bacterial proliferation. Mtb-IN-10 holds potential for tuberculosis TB research, particularly for combating multidrug-resistant MDR-TB and extensively drug-resistant XDR-TB Mtb strains.