MuCaP376 Cells

Description

MuCaP376 is an epithelial prostate cancer cell line from the PSA-Cre targeted Pten KO primary tumors in FVB mice. It forms syngeneic tumors with moderate growth rates in immunocompetent mice, achieving substantial tumor volumes within 1-2 months. These tumors exhibit heterogeneous histologies, including intraductal carcinoma IDC , adenocarcinoma, and sarcomatoid carcinoma, reflecting the primary Pten KO tumor characteristics. MuCaP376 also shows PI3K pathway activation and is responsive to PI3K inhibitors like GDC0941. This cell line is valuable for studying prostate cancer heterogeneity, tumor aggressiveness, and immune interactions, including moderate levels of CD3+ T-cell infiltration. Additional cell lines from the MuCaP model: Cat. T8301 - MuCaP321 Cells Cat. T8303 - MuCaP379AP Cells Cat. T8304 - MuCaP379.1 Cells