Murrayafoline A

Description

Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 Sp1 , thereby inhibiting NF-?B and MAPK signaling pathways. Murrayafoline a induces a G0/G1-phase arrest in platelet-derived growth factor PDGF -stimulated vascular smooth muscle cells. Murrayafoline A attenuates the Wnt/?-catenin pathway by promoting the degradation of intracellular ?-catenin proteins. Murrayafoline A enhances the contraction of rat ventricular myocytes and L-type calcium current by activating protein kinase C. Murrayafoline A inhibits LPS HY-D1056 -induced neuroinflammation in vivo. Murrayafoline A can be used for the study of inflammation, vascular complications and colon cancer.