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Mutant IDH1-IN-7
GENERAL CATALOGUE

Mutant IDH1-IN-7

HY-175213 · 50 mg

MedChemExpress · Cat: HY-175213

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Catalog No: HY-175213
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress

Description

Mutant IDH1-IN-7 is a highly selective Isocitrate Dehydrogenase 1 IDH1 R132H IC50 = 0.26 ?M, Kd = 2.1 ?M /R132C IC50 = 1.1 ?M inhibitor. Mutant IDH1-IN-7 has no inhibitory effect on wild-type IDH1, IDH2-wt, and IDH2 R140Q. Mutant IDH1-IN-7 inhibits 2-Hydroxyglutarate 2-HG production in U87-MG R132H cells EC50 = 0.55 ?M . Mutant IDH1-IN-7 exhibits moderate antiproliferative effects on U87-MG R132H and HT-1080 cells.

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