Mutated EGFR-IN-2

Description

Mutated EGFR-IN-2 compound 91 is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR T790M and double-mutant EGFR including L858R/T790M IC50=?1nM and ex19del/T790M , and can suppress activity of single gain-of-function mutant EGFR including L858R and ex19del as well. Mutated EGFR-IN-2 shows anti-tumor antivity.