N-(3-Oxohexanoyl)-L-homoserine lactone

Description

N- 3-Oxohexanoyl -L-homoserine lactone OHHL; N- 3-Oxohexanoyl homoserine lactone is a specific agonist of LuxR-type transcription factor CarR with a Kd of 1.8 ?M. N- 3-Oxohexanoyl -L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N- 3-Oxohexanoyl -L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N- 3-Oxohexanoyl -L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica.