N'-Isonicotinoylisonicotinohydrazide

Description

N-Isonicotinoylisonicotinohydrazide Compound 7, 1,2-Diisonicotinoylhydrazine is a competitive inhibitor IC50=5-30 ?M of bacterial heme oxygenase HO . N-Isonicotinoylisonicotinohydrazide inhibits iron release and bacterial iron acquisition. N-Isonicotinoylisonicotinohydrazide exhibits selective activity against HO enzymes from Pseudomonas aeruginosa and Neisseria meningitidis. N-Isonicotinoylisonicotinohydrazide is promising for research of multidrug-resistant Gram-negative bacterial infections.