N-Methylarachidonamide

Description

Anandamide AEA is an endogenous cannabinoid that binds to both central cannabinoid CB1 and peripheral cannabinoid CB2 receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid CB1 receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100 % at a concentration of 50 ?M.