N-Methylmesoporphyrin IX

Description

N-Methylmesoporphyrin IX NMM , a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring A? fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for A? amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric A? environments, but emits strong fluorescence through stacking with the A? assemblies.