GENERAL CATALOGUE
N-(p-Coumaroyl) Serotonin
HY-129440 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-129440
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Manufacturer product page
medchemexpress.com/n-p-coumaroyl-serotonin.htmlCatalog No: HY-129440
CAS No: 68573-24-0
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
N- p-Coumaroyl Serotonin is a selective inhibitor of PDGFR?, ERK1/2 and caspase-8 with antioxidant, anti-atherosclerotic and anti-inflammatory properties. N- p-Coumaroyl Serotonin inhibits glioblastoma cells U251MG, T98G with IC50 of 48-81 ?M, while the IC50 for normal fibroblasts is 181-197 ?M. N- p-Coumaroyl Serotonin inhibits PDGF signaling reducing receptor phosphorylation , blocks Ca2+ influx, and induces apoptosis activating caspase-8 . N- p-Coumaroyl Serotonin can improve atherosclerosis and aortic wall enlargement, and can also be used in the study of glioblastoma.
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