N6-Methyladenosine (Standard)

Description

N6-Methyladenosine Standard is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal non-cap modification present in the messenger RNA mRNA of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine m6A is selectively recognized by the human YTH domain family 2 YTHDF2 protein to regulate mRNA degradation. N6-methyladenosine m6A , a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase e.g., MT-A70 within the consensus sequence of G m6A C 70 % or A m6A C 30 % . N6-methyladenosine m6A -containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion. N6-methyladenosine m6A , the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine m6A is a large protein complex, consisting in part of methyltransferase-like 3 METTL3 and methyltransferase-like 14 METTL14 catalytic subunits.