NAB815

Description

NAB815 is a specific inhibitor of the Stx2a Kd = 0.01 ?M /TLR4 interaction. NAB815 inhibits the neutrophil/Stx2a interaction IC50 = 0.057 ?g/mL . NAB815 inhibits the formation of Stx2-containing extracellular vesicles EVs produced by leukocytes and platelets and reduces their toxic effects in cellular Vero cells and animal models CD-1 mice . NAB815 reduces bacterial loads in the kidneys, urine, and bladders of Escherichia coli-infected mice. NAB815 is useful in the study of hemolytic uremic syndrome HUS .