

HY-152154 · 5 mg
MedChemExpress · Cat: HY-152154
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medchemexpress.com/nampt-degrader-2.htmlDescription
Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system UPS . Nampt degrader-2 leads to significant reduction of NAD+ and exerts potent antitumor activities.







