NAV3 Rabbit Polyclonal Antibody

Description

EnkiLife offers the NAV3 Rabbit Polyclonal Antibody. This antibody reacts with Human,Rat,Mouse species and is suitable for IHC,ICC/IF application. . The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:50-1:300,ICC/IF 1:50-1:200 Background: This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008],developmental stage:Expressed in fetal brain.,disease:Defects in NAV3 may be a cause of mycosis fungoides [MIM:254400]; a malignant T-cell lymphoma of the skin.,disease:Defects in NAV3 may be a cause of Sezary syndrome, a malignant T-cell lymphoma of the skin.,function:May regulate IL2 production by T-cells. May be involved in neuron regeneration.,similarity:Belongs to the Nav/unc-53 family.,similarity:Contains 1 CH (calponin-homology) domain.,tissue specificity:Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.,