GENERAL CATALOGUE
NAZ2329
HY-103693 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-103693
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medchemexpress.com/naz2329.htmlCatalog No: HY-103693
CAS No: 2809469-05-2
Category: Metabolic Enzyme Protease
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases RPTPs , allosterically and preferentially inhibits PTPRZ IC50=7.5 AAasAasAAmuM for hPTPRZ1 and PTPRG IC50=4.8 AAasAasAAmuM for hPTPRG over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment IC50 of 1.1 AAasAasAAmuM than the whole intracellular D1?+?D2 fragment IC50 of 7.5 AAasAasAAmuM . NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties.
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