GENERAL CATALOGUE
NBI 35965 hydrochloride
HY-110056 · 5 mg
MedChemExpress · Cat: HY-110056
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Catalog No: HY-110056
CAS No: 1782228-59-4
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
NBI 35965 hydrochloride is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 CRF1 antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 hydrochloride does not inhibit CRF2. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone ACTH production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride shows anxiolytic effects.
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