GENERAL CATALOGUE
NBI 35965 methanesulfonate
HY-103378 · 1 mg
MedChemExpress · Cat: HY-103378
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medchemexpress.com/nbi-35965-methanesulfonate.htmlCatalog No: HY-103378
CAS No: 603151-83-3
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 CRF1 antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone ACTH production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects.
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