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NC1153
GENERAL CATALOGUE

NC1153

HY-115464 · 50 mg

MedChemExpress · Cat: HY-115464

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medchemexpress.com/nc1153.html
Catalog No: HY-115464
CAS No: 150661-91-9
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress

Description

NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A CsA can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity.

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