

HY-115464 · 50 mg
MedChemExpress · Cat: HY-115464
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medchemexpress.com/nc1153.html
Description
NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A CsA can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity.







