

HY-145102 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-145102
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Manufacturer product page
medchemexpress.com/nct-58.html
Description
NCT-58 is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response HSR due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.







