GENERAL CATALOGUE
NCX 466
HY-103388 · 50 mg
MedChemExpress · Cat: HY-103388
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medchemexpress.com/ncx-466.htmlCatalog No: HY-103388
CAS No: 1262956-64-8
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
NCX 466 is an orally active COX-1 and COX-2 inhibitor that exhibits anti-inflammatory and analgesic effects. Additionally, NCX 466 acts as a NO donor, exerting anti-inflammatory and antioxidant effects by improving microcirculation. NCX 466 significantly reduces the levels of transforming growth factor-? TGF-? and oxidative stress markers such as thiobarbituric acid reactive substances TBARS and 8-hydroxy-2-deoxyguanosine 8-OHdG , and it decreases leukocyte recruitment during inflammation by reducing myeloperoxidase MPO activity, thereby preventing bleomycin HY-108345 -induced pulmonary fibrosis in mice.
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