GENERAL CATALOGUE
NDI-091143
HY-127111 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-127111
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Manufacturer product page
medchemexpress.com/ndi-091143.htmlCatalog No: HY-127111
CAS No: 2375840-87-0
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
NDI-091143 is a potent and high-affinity human ATP-citrate lyase ACLY inhibitor with an IC50 of 2.1 nM ADP-Glo assay , a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate.
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