GENERAL CATALOGUE
Necrocide 1
HY-14307 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-14307
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Catalog No: HY-14307
CAS No: 1247028-61-0
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Necrocide 1, a necrosis by sodium overload NECSO inducer, is a selective transient receptor potential melastatin 4 TRPM4 agonist with an EC50 of 306.3 nM for human TRPM4. Necrocide 1 triggers TRPM4-dependent necrotic cell death through the induction of sodium influx. Necrocide 1 induces hallmarks of immunogenic cell death incurring calreticulin CALR exposure, ATP secretion and high mobility group box 1 HMGB1 release. Necrocide 1 can be used for the study of breast and prostate cancer.
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