GENERAL CATALOGUE
NecroIr2
HY-148366 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-148366
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medchemexpress.com/necroir2.html
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Catalog No: HY-148366
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
NecroIr2 is an iridium III complex, serves as necroptosis inducers in Cisplatin HY-17394 -resistant lung cancer cells A549R . NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential MMP . NecroIr2 activates receptor-interacting serine-threonine kinase 3 RIPK3 and mixed lineage kinase domain-like pseudokinase MLKL , and regulates CDK4 expression.
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