Nectin-3/CD113 hFc Chimera, Human

Description

The Nectin family has at least four members Nectin-14 , all of which show alternate splicing, a transmembrane TM region except for Nectin-1 gamma , and three extracellular Ig-domains. Nectins are highly homologous to the human receptor for poliovirus, and as such, have been alternatively-named poliovirus receptor-related proteins. They do not, however, appear to bind poliovirus. Nectin-3 also named PRR3, CD113, and PVRL3 is an 83 kDa, type I TM glycoprotein. Its precursor is 549 amino acids aa in length. It contains an extended signal sequence of 57 aa, an extracellular domain ECD of 347 aa, a transmembrane segment of 21 aa aa 405-425 , and a cytoplasmic region of 124 amino acids.