GENERAL CATALOGUE
Nedisertib
HY-101570 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-101570
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Catalog No: HY-101570
CAS No: 1637542-33-6
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Nedisertib Peposertib is an orally active selective DNA-dependent protein kinase DNA-PK inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance MDR , thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity.
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