Negletein

Description

Negletein 5,6-Dihydroxy-7-methoxyflavone is a flavone found in Scutellaria. Negletein shows anti-inflammatory activity via inhibiting TNF-? and IL-1? with IC50 values of 16.4 and 6.4 ?M, respectively. Negletein can activate Nrf2 and inhibit ROS production. Negletein can enhance the neuroprotective effect of nerve growth factor. Negletein can inhibit amyloid beta-peptide release and accumulation. Negletein can inhibit pathogens biofilms formation. Negletein can be used for the researches of cancer, infection, inflammation and neurological disease, such as colon cancer and Alzheimers disease.