GENERAL CATALOGUE
NEO214
HY-124582 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-124582
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Catalog No: HY-124582
CAS No: 1361198-80-2
Category: Autophagy
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram HY-16900 and perillyl alcohol HY-N7000 . It has anti-cancer activity and blood-brain barrier BBB permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB Transcription Factor EB aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma.
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