Neoaureothin

Description

Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor AR antagonist that inhibits binding of dihydrotestosterone DHT to ARs IC50=13 ?M and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells IC50=1.75 nM . Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells IC50s=34.3, 47, and 37.2 ?g/mL, respectively . It also has nematocidal activity against the pine wood nematode B. xylophilus LC50=0.84 ?g/mL and increases survival of P. densiflora trees inoculated with B. xylophilus.