GENERAL CATALOGUE
Neptinib
HY-164503 · 5 mg
MedChemExpress · Cat: HY-164503
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medchemexpress.com/neptinib.html
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Catalog No: HY-164503
CAS No: 2085843-51-0
Category: JAK STAT Signaling
Pack Size: 5 mg
Brand: MedChemExpress
Description
Neptinib NEP010 is an orally active derivative of Afatinib HY-10261 that has stronger antitumor activity than Afatinib HY-10261 by improving pharmacokinetics. Neptinib has a significant inhibitory effect on tumor growth in mouse non-small cell lung cancer models with different EGFR mutations. Neptinib has a certain inhibitory effect on the EGFR kinase family, with IC50 values ??of 0.24 nM, 7.25 nM, 0.46 nM and 1.79 nM for EGFRwt, EGFRL858R/T790M, EGFRL858R and EGFRT790M, respectively.
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