Neuroprotective agent 5

Description

Neuroprotective agent 5 compound 28 is a brain permeabilizing agent with anti-neuritis, anti-oxidative damage and neuroprotective effects. Neuroprotective agent 5 exhibits a potent NO inhibitory effect EC50=0.49 ?M , inhibits the release of proinflammatory factors PGE2 and TNF-?, downregulates the expression of iNOS and COX-2 proteins, and promotes the polarization of BV-2 cells from the proinflammatory M1 phenotype to the anti-inflammatory M2 phenotype. In addition, Neuroprotective agent 5 can also inhibit acetylcholinesterase AChE activity and A?42 aggregation in a dose-dependent manner. Neuroprotective agent 5 can be used for the study of Alzheimers disease.