NF-?B-IN-16

Description

NF-?B-IN-16 compound 9 is a complex Pt IV complex of NF-?B inhibitor and Cisplatin HY-17394 , which has high efficacy and low toxicity in anti-tumor activity. active. NF-?B-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-?B-IN-16 potently inhibits the NF-?B/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-?B-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models.