NF-κB p65 Mouse Monoclonal Antibody

Description

EnkiLife offers the NF-κB p65 Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat,Rabbit,Monkey species and is suitable for WB,IHC,ELISA application. Alternative Names of Immunogen: NFkappaB p65; p65; NFKB3; RELA. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:100-1:500,ELISA 1:5000-1:20000 Background: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Research Area: PI3K-Akt signaling pathway,MAPK signaling pathway