GENERAL CATALOGUE
NF157
HY-108672 · 1 mg
MedChemExpress · Cat: HY-108672
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Catalog No: HY-108672
CAS No: 104869-26-3
Category: GPCR G Protein
Pack Size: 1 mg
Brand: MedChemExpress
Description
NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. The IC50s are 463 nM, 1811 AAasAasAAmuM, 170 AAasAasAAmuM for P2Y11 Ki=44.3 nM , P2Y1 Ki=187 AAasAasAAmuM , P2Y2 Ki=28.9 AAasAasAAmuM , respectively. NF157, significantly reduces expression of metalloproteinase MMP -3, MMP-13, can be used in the treatment of osteoarthritis OA .